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Updated: May 14, 2026

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster
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Expression and function of scalloped during Drosophila development.

Kirsten A Guss1, Michael Benson, Nicholas Gubitosi

  • 1Department of Biology, Dickinson College, Carlisle, Pennsylvania 17013, USA. gussk@dickinson.edu

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|February 8, 2013
PubMed
Summary

Scalloped (sd) protein is expressed throughout Drosophila embryogenesis, particularly in the nervous system and muscles. Its function is crucial for motor neuron innervation, revealing new roles beyond wing development.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Neuroscience

Background:

  • The genes scalloped (sd) and vestigial (vg) are known to interact in Drosophila wing development.
  • Limited information exists regarding the expression patterns of the scalloped protein (SD) during development.
  • The potential for sd and vg interaction in tissues beyond wings remains largely unexplored.

Purpose of the Study:

  • To characterize the expression patterns of SD during Drosophila embryogenesis.
  • To investigate the functional requirements of sd in various developing tissues.
  • To explore potential co-expression and interactions between SD and VG proteins.

Main Methods:

  • Generation of a specific anti-SD antibody for protein detection.
  • Immunohistochemical analysis of SD expression in embryonic and larval Drosophila.

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Last Updated: May 14, 2026

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster
10:10

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

Upright Imaging of Drosophila Embryos
07:34

Upright Imaging of Drosophila Embryos

Published on: September 13, 2010

Imaging Dpp Release from a Drosophila Wing Disc
06:12

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Published on: October 30, 2019

  • Phenotypic analysis of sd mutants to assess functional requirements.

    • Main Results:

    • SD is broadly expressed in the central and peripheral nervous systems, musculature, and developing flight appendages during embryogenesis.
    • While not essential for specifying certain neurons (e.g., mVUMs), sd function is critical for their proper innervation of somatic muscles.
    • SD and VG proteins exhibit overlapping and distinct expression patterns in embryonic and larval tissues, suggesting complex interactions.

    Conclusions:

    • This study comprehensively maps SD expression across Drosophila embryogenesis.
    • A novel requirement for sd function in a subset of motor neurons is identified.
    • The findings establish a foundation for future research into the developmental roles of sd.