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Published on: November 8, 2012
Compressed sensing reconstruction improves sensitivity of variable density spiral fMRI.
1Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Magnetic Resonance in Medicine
|February 8, 2013
Summary
Compressed sensing (CS) reconstruction enhances functional MRI (fMRI) sensitivity. Variable density (VD) spiral fMRI with CS at 28% under-sampling achieves sensitivity comparable to conventional 2-shot methods but with single-shot acquisition.
Area of Science:
- Neuroimaging
- Magnetic Resonance Imaging
Background:
- Functional MRI (fMRI) is crucial for brain activity studies.
- Demand exists for fMRI techniques with high contrast, rapid imaging, and minimal distortion.
Purpose of the Study:
- To investigate if compressed sensing (CS) reconstruction can improve fMRI sensitivity.
- To evaluate CS reconstruction of variable density (VD) spiral fMRI.
Main Methods:
- Compared three CS-reconstructed 1-shot VD spirals (28%, 35%, 46% under-sampling) with conventional 1-shot and 2-shot Archimedean spirals.
- Assessed fMRI map sensitivity with and without CS reconstruction using matched voxels.
Main Results:
- CS reconstruction increased functional contrast only at 28% under-sampling.
- 2-shot uniformly sampled spiral and 28% under-sampled VD spiral data reconstructed with CS showed equivalent sensitivity.
Conclusions:
- VD spiral fMRI with CS reconstruction offers improved sensitivity in the 25-30% under-sampling range.
- CS enables VD acquisitions to match the sensitivity of 2-shot Archimedean acquisitions using only a single shot.
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