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Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Related Experiment Video

Updated: May 14, 2026

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo
10:35

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

Targeting dendritic cells--why bother?

Martin Kreutz1, Paul J Tacken, Carl G Figdor

  • 1Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.

Blood
|February 8, 2013
PubMed
Summary
This summary is machine-generated.

Targeting vaccines to dendritic cells (DCs) can enhance T-cell immunity, a key challenge in immunotherapy. This perspective explores the benefits, drawbacks, and optimal strategies for DC targeting in vaccine development.

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Last Updated: May 14, 2026

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10:35

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Published on: February 5, 2021

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Area of Science:

  • Immunology
  • Vaccinology
  • Cellular Immunity

Background:

  • Vaccination is a powerful immunotherapy, but inducing robust T-cell responses remains difficult.
  • Dendritic cells (DCs) are key players in T-cell priming, making them attractive targets for vaccine strategies.
  • Different DC subsets possess unique functions, necessitating tailored targeting approaches for optimal immune activation.

Purpose of the Study:

  • To review the advantages and disadvantages of targeting dendritic cells (DCs) for vaccine development.
  • To discuss the current controversies regarding the most effective DC subsets for immunotherapy.
  • To evaluate promising vaccine delivery systems and immunization routes for DC activation.

Main Methods:

  • Review of current literature on dendritic cell targeting in vaccination.
  • Analysis of different DC subsets and their roles in T-cell priming.
  • Evaluation of various vaccine delivery systems and immunization routes.

Main Results:

  • Targeting antigens to DCs can improve cellular immunity, but effectiveness varies by DC subset.
  • The choice of DC subset and targeting strategy significantly impacts T-cell responses.
  • Delivery systems that target multiple vaccine components to DCs show promise.

Conclusions:

  • Targeting specific dendritic cell subsets offers a promising strategy to enhance T-cell mediated immunity in vaccines.
  • Further research is needed to identify optimal DC targets and delivery systems for effective immunotherapy.
  • Careful consideration of vaccine vehicles and immunization routes is crucial for successful DC-targeted vaccination.