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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

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Related Experiment Video

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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
11:36

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Published on: April 21, 2012

Drug discovery algorithm for cutaneous leishmaniasis.

Max Grogl1, Mark Hickman, William Ellis

  • 1Division Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. max.grogl1@us.army.mil

The American Journal of Tropical Medicine and Hygiene
|February 8, 2013
PubMed
Summary
This summary is machine-generated.

Developing new treatments for cutaneous leishmaniasis is crucial. This study outlines a novel preclinical drug discovery scheme focusing on in vitro and in vivo testing for efficacy and safety to identify promising oral candidates.

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Area of Science:

  • Parasitology
  • Drug Discovery
  • Tropical Medicine

Background:

  • Cutaneous leishmaniasis is a widespread neglected tropical disease with limited effective and well-tolerated therapeutic options.
  • Existing treatments for cutaneous leishmaniasis were approved without standardized preclinical evaluation, hindering the development of new drug candidates.
  • There is a critical need for a robust preclinical discovery scheme to identify novel, orally available agents for cutaneous leishmaniasis.

Purpose of the Study:

  • To establish and implement a comprehensive preclinical drug discovery scheme for identifying novel oral therapeutic agents for cutaneous leishmaniasis.
  • To integrate in vitro and in vivo efficacy, toxicity, and pharmacokinetic/metabolism assessments into the discovery pipeline.
  • To prioritize in vivo models with high clinical relevance and optimize resource utilization for efficient candidate selection.

Main Methods:

  • Implementation of a multi-stage discovery scheme incorporating in vitro screening and in vivo efficacy models.
  • Systematic evaluation of drug candidates for efficacy, toxicity, and pharmacokinetic/metabolism profiles.
  • Progression of candidates through increasingly complex and clinically relevant in vivo models, from high-throughput to specialized systems.

Main Results:

  • The developed scheme successfully incorporates essential preclinical assessments for drug candidate evaluation.
  • Emphasis on in vivo testing allows for a more accurate prediction of clinical efficacy and safety.
  • The structured approach facilitates efficient resource allocation in the drug discovery process.

Conclusions:

  • The implemented discovery scheme provides a framework for the rational development of new oral treatments for cutaneous leishmaniasis.
  • This approach addresses the limitations of existing drug development pathways by incorporating rigorous preclinical evaluation.
  • The scheme is designed to yield promising drug candidates with improved efficacy and tolerability profiles for clinical development.