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Changes in Streptococcus pneumoniae serotype 19A invasive infections in children from 1993 to 2011

Kristina G Hulten1, Sheldon L Kaplan, Linda B Lamberth

  • 1Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA. khulten@bcm.edu

Journal of Clinical Microbiology
|February 8, 2013
PubMed

Insights

Multidrug-resistant Streptococcus pneumoniae serotype 19A, particularly CC320, caused invasive pneumococcal disease (IPD). This strain showed reduced susceptibility to common antibiotics even after the introduction of the pneumococcal conjugate vaccine 13 (PCV13).

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Streptococcus pneumoniae causes invasive pneumococcal disease (IPD).
  • Serotype 19A isolates have been a concern due to antibiotic resistance.
  • The introduction of pneumococcal conjugate vaccine 13 (PCV13) aimed to reduce IPD incidence.

Purpose of the Study:

  • To characterize the genetic diversity and antimicrobial resistance profiles of Streptococcus pneumoniae serotype 19A isolates.
  • To assess the impact of PCV13 introduction on the prevalence of specific sequence types, including CC320.

Main Methods:

  • Multilocus sequence typing (MLST) was used to determine the genetic relatedness of 594 IPD isolates collected between 1993 and 2011.
  • Antimicrobial susceptibility testing was performed.

Main Results:

  • Eighty-five distinct sequence types (STs) were identified among the 594 isolates.
  • CC320 was a predominant clone associated with multidrug resistance and reduced susceptibility to penicillin and ceftriaxone.
  • CC320 isolates remained prevalent among declining serotype 19A IPD isolates post-PCV13 introduction.

Conclusions:

  • CC320 represents a significant multidrug-resistant clone of Streptococcus pneumoniae serotype 19A.
  • The emergence and persistence of CC320 highlight the need for ongoing surveillance of antimicrobial resistance in pneumococcal isolates, even after vaccine implementation.

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