Better drug discovery through better target identification.

Area of Science:

• Drug discovery and development
• Biotechnology
• Chemical biology

Background:

• High-throughput screening (HTS) was introduced a decade ago as a transformative technology for research and development.
• Despite its potential to reduce R&D costs by hundreds of millions of dollars, HTS has not yet met initial expectations.
• The field is now focused on advancing HTS to overcome previous limitations.

Purpose of the Study:

• To evaluate the current status and future potential of high-throughput screening.
• To highlight the advancements in second-generation HTS techniques.
• To assess the progress of HTS in meeting its projected impact on R&D costs.

Main Methods:

• Review of second-generation high-throughput screening technologies.
• Analysis of the impact of HTS on research and development costs.
• Assessment of the progress and challenges in HTS implementation.

Main Results:

• Second-generation HTS techniques are showing significant promise.
• The full potential of HTS in reducing R&D costs is closer to being realized.
• Ongoing advancements are addressing the limitations of earlier HTS approaches.

Conclusions:

• High-throughput screening technology is evolving and nearing its anticipated impact.
• Second-generation HTS methods are key to unlocking cost-saving potentials in R&D.
• The future of drug discovery and development is being shaped by advanced HTS.