Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...

What is Evolutionary History?

What is Evolutionary History?

Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.

Disassembly of Intermediate Filaments

Disassembly of Intermediate Filaments

Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...

Origin of Cellular Life

Origin of Cellular Life

The origin of life on Earth is a complex and enigmatic event rooted in ancient biochemical processes and geological conditions. Experimental evidence supports the hypothesis that life began with the spontaneous formation of organic molecules such as RNA nucleotides, amino acids, and lipids under early Earth conditions. Factors like volcanic activity, intense UV radiation, and a reducing atmosphere without free oxygen likely facilitated these reactions. Hydrothermal vents on the ocean floor are...

Conditions on Early Earth

Conditions on Early Earth

Around 4 billion years ago, oceans began to condense on earth while volcanic eruptions released nitrogen, carbon dioxide, methane, ammonia, and hydrogen into the primordial atmosphere. However, organisms with the characteristics of life were not initially present on earth. Scientists have used experimentation to determine how organisms evolved that could grow, reproduce, and maintain an internal environment.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A male-derived volatile sex pheromone in Caenorhabditis nematodes identified through its mimicry by a predator.

Communications biology·2026

Same author

Identification of <i>srh-30</i> as a 2-nonanone receptor in <i>C. elegans</i>.

bioRxiv : the preprint server for biology·2026

Same author

Joubert syndrome gene <i>fam149b1</i> homolog, <i>xbx-4</i> , is required for multiple sensory behaviors.

microPublication biology·2026

Same author

Amino Acid Substitutions in the Na<sup>+</sup>/K<sup>+</sup>-ATPase May Contribute to Salinity Tolerance in Insects.

Ecological entomology·2026

Same author

Entomopathogenic Nematode <i>Steinernema carpocapsae</i> Venom Proteins Disrupt Developmental Physiology and Reproduction of <i>Spodoptera frugiperda</i> (Lepidoptera: Noctuidae).

Toxins·2026

Same author

Whole-organism spatial transcriptomics at single-cell resolution in <i>C. elegans</i>.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: May 14, 2026

Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria

Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria

Published on: January 25, 2019

Origin and evolution of dishevelled.

Adler R Dillman¹, Paul J Minor, Paul W Sternberg

¹Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

G3 (Bethesda, Md.)

|February 8, 2013

Summary

Dishevelled (Dsh) protein evolution shows dynamic changes, especially in nematodes, with new domains and nuclear signals suggesting functional specialization in Wnt signaling pathways.

Keywords:

C. elegans Nematoda Wnt dishevelled protein evolution

More Related Videos

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face

Published on: January 7, 2019

Related Experiment Videos

Last Updated: May 14, 2026

Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria

Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria

Published on: January 25, 2019

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face

Reverse Dissection and DiceCT Reveal Otherwise Hidden Data in the Evolution of the Primate Face

Published on: January 7, 2019

Area of Science:

Evolutionary developmental biology
Molecular signaling pathways
Comparative genomics

Background:

Dishevelled (Dsh) is a crucial signaling protein in Wnt pathways, essential for various developmental processes.
Dsh is highly conserved across metazoans and has diversified into multiple genes in many animal lineages.
While Dsh orthologs often show functional overlap, evidence for specialization is increasing.

Purpose of the Study:

To conduct a comparative analysis of Dishevelled (Dsh) protein architecture across diverse animal species.
To identify conserved and divergent features of Dsh, focusing on invertebrates like nematodes, to understand functional specialization.
To explore the evolutionary dynamics of Dsh, particularly its role as a central signaling hub.

Main Methods:

Comparative analysis of Dishevelled (Dsh) protein sequences and structures across various animal taxa.
Bioinformatic identification of conserved and novel protein domains.
Analysis of predicted protein localization signals, such as nuclear localization signals.

Main Results:

Evidence of dynamic evolution in Dsh, with nematode lineages exhibiting variable ortholog numbers (one to three).
Identification of a novel protein domain unique to certain nematode Dsh orthologs.
Discovery of a conserved, unexpected nuclear localization signal in numerous Dsh orthologs.

Conclusions:

The evolution of Dishevelled (Dsh) is complex, with significant diversification observed, especially within nematodes.
The identified novel domain and conserved nuclear localization signal suggest mechanisms for functional specialization.
Findings provide insights into protein evolution and how organisms manage complex signaling networks, generating testable hypotheses.