Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sampling Continuous Time Signal01:11

Sampling Continuous Time Signal

In signal processing, a continuous-time signal can be sampled using an impulse-train sampling technique, followed by the zero-order hold method. Impulse-train sampling involves the use of a periodic impulse train, which consists of a series of delta functions spaced at regular intervals determined by the sampling period. When a continuous-time signal is multiplied by this impulse train, it generates impulses with amplitudes corresponding to the signal's values at the sampling points.
In the...
Basic Continuous Time Signals01:22

Basic Continuous Time Signals

Basic continuous-time signals include the unit step function, unit impulse function, and unit ramp function, collectively referred to as singularity functions. Singularity functions are characterized by discontinuities or discontinuous derivatives.
The unit step function, denoted u(t), is zero for negative time values and one for positive time values, exhibiting a discontinuity at t=0. This function often represents abrupt changes, such as the step voltage introduced when turning a car's...
Continuous -time Fourier Transform01:11

Continuous -time Fourier Transform

The Fourier series is instrumental in representing periodic functions, offering a powerful method to decompose such functions into a sum of sinusoids. This technique, however, necessitates modification when applied to nonperiodic functions. Consider a pulse-train waveform consisting of a series of rectangular pulses. When these pulses have a finite period, they can be accurately represented by a Fourier series. Yet, as the period approaches infinity, resulting in a single, isolated pulse, the...
Continuous Charge Distributions01:17

Continuous Charge Distributions

Imagine a bucket of water. It contains many molecules, of the order of 1026 molecules. Thus, although it contains discrete elements (molecules) at the microscopic level, macroscopically, it can be considered continuous. Small volume elements of water, infinitesimal compared to the bulk of the bucket's volume, still contain many molecules. Under this framework, quantized matter is approximated as continuous for practical purposes.
The electric charge can also be subjected to an analogical...
BIBO stability of continuous and discrete -time systems01:24

BIBO stability of continuous and discrete -time systems

System stability is a fundamental concept in signal processing, often assessed using convolution. For a system to be considered bounded-input bounded-output (BIBO) stable, any bounded input signal must produce a bounded output signal. A bounded input signal is one where the modulus does not exceed a certain constant at any point in time.
To determine the BIBO stability, the convolution integral is utilized when a bounded continuous-time input is applied to a Linear Time-Invariant (LTI) system.
Region of Convergence of Laplace Tarnsform01:20

Region of Convergence of Laplace Tarnsform

The Region of Convergence (ROC) is a fundamental concept in signal processing and system analysis, particularly associated with the Laplace transform. The ROC represents an area in the complex plane where the Laplace transform of a given signal converges, determining the transform's applicability and utility.
Consider a decaying exponential signal that begins at a specific time. When deriving its Laplace transform, the time-domain variable is replaced with a complex variable. This substitution...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term evolution of regulatory DNA sequences. Part 2: theory and future challenges.

Current opinion in genetics & development·2026
Same author

Genetic prediction with ARG-powered linear algebra.

Genetics·2026
Same author

Tracing the evolutionary histories of ultra-rare variants using variational dating of large ancestral recombination graphs.

bioRxiv : the preprint server for biology·2026
Same author

A Pandemic-Scale Ancestral Recombination Graph for SARS-CoV-2.

bioRxiv : the preprint server for biology·2025
Same author

On ARGs, pedigrees, and genetic relatedness matrices.

Genetics·2025
Same author

Accessible, Realistic Genome Simulation with Selection Using stdpopsim.

Molecular biology and evolution·2025
Same journal

conMItion: an R package adjusting confounding factors for associations in multi-omics.

Bioinformatics (Oxford, England)·2026
Same journal

SpaMFG: a Spatial Multi-omics Integration Method based on Feature Grouping.

Bioinformatics (Oxford, England)·2026
Same journal

CSCN: Inference of Cell-Specific Causal Networks Using Single-Cell RNA-Seq Data.

Bioinformatics (Oxford, England)·2026
Same journal

Sparse CCA-Based Mediation Analysis with High-Dimensional Exposures and Mediators.

Bioinformatics (Oxford, England)·2026
Same journal

Enhancing Cross-Context Generalization in Drug Perturbation Prediction with a Multimodal Conditional Diffusion Framework.

Bioinformatics (Oxford, England)·2026
Same journal

Primer Design through Submodular Function Estimation.

Bioinformatics (Oxford, England)·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures
10:56

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures

Published on: May 20, 2014

Coalescent simulation in continuous space.

Jerome Kelleher1, Nicholas H Barton, Alison M Etheridge

  • 1Institute of Evolutionary Biology, University of Edinburgh, King's Buildings, West Mains Road, EH9 3JT, UK. jerome.kelleher@ed.ac.uk

Bioinformatics (Oxford, England)
|February 9, 2013
PubMed
Summary
This summary is machine-generated.

Coalescent simulation now includes spatial structure, enabling the study of gene ancestry in continuous populations. This new method overcomes limitations of previous models, offering a robust approach for evolutionary genetics research.

More Related Videos

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis
06:44

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis

Published on: September 23, 2025

Related Experiment Videos

Last Updated: May 14, 2026

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures
10:56

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures

Published on: May 20, 2014

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis
06:44

Age-dependent Dynamics of Locomotion in Caenorhabditis elegans: A Lyapunov Exponent Analysis

Published on: September 23, 2025

Area of Science:

  • Population genetics
  • Evolutionary biology
  • Computational biology

Background:

  • Coalescent simulation is vital for population genetics.
  • Simulating spatial population structure has been challenging.
  • Previous models like isolation by distance faced technical issues.

Purpose of the Study:

  • To present a detailed algorithm for coalescent simulation in continuous space.
  • To provide an efficient, generalized Python implementation of the algorithm.
  • To enable the study of populations with spatial structure.

Main Methods:

  • Developed a novel algorithm for coalescent simulation in continuous space.
  • Implemented a generalized version of the algorithm in Python.
  • Leveraged a recently introduced model that resolves technical challenges of spatial structure.

Main Results:

  • Successfully simulated the coalescent process in a spatial continuum.
  • Created a freely available Python module for efficient simulation.
  • The new model provides a solid theoretical basis for spatial population genetics.

Conclusions:

  • The developed algorithm and Python module facilitate the study of spatially structured populations.
  • This work addresses a long-standing challenge in coalescent simulation.
  • Enables new research into the evolutionary dynamics of populations in continuous space.