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Cocaine facilitates prefrontal cortex self-stimulation.

C A Moody1, R A Frank

  • 1Department of Psychology, University of Cincinnati, OH 45221-0376.

Pharmacology, Biochemistry, and Behavior
|March 1, 1990
PubMed
Summary
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Cocaine hydrochloride (HCl) enhances self-stimulation in the brain's reward pathways, specifically the prefrontal cortex. This suggests cocaine may influence dopamine systems, though its exact role remains under investigation.

Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Behavioral Science

Background:

  • Cocaine hydrochloride (HCl) is known to affect reward pathways in the brain.
  • Previous research indicates cocaine HCl lowers thresholds and increases rates of medial forebrain bundle intracranial self-stimulation.
  • The prefrontal cortex may have a different neuroanatomical and pharmacological basis for self-stimulation compared to the medial forebrain bundle.

Purpose of the Study:

  • To assess the influence of cocaine on prefrontal cortex self-stimulation.
  • To compare the effects of cocaine on prefrontal cortex self-stimulation with its known effects on the medial forebrain bundle.

Main Methods:

  • Intracranial self-stimulation was used to measure the effects of cocaine on prefrontal cortex activity.

Related Experiment Videos

  • Train-duration thresholds and self-stimulation rates were recorded.

    • Main Results:

    • Cocaine significantly decreased train-duration thresholds for prefrontal cortex self-stimulation.
    • Cocaine significantly increased the rate of prefrontal cortex self-stimulation.
    • These findings indicate cocaine facilitates self-stimulation at this site.

    Conclusions:

    • Cocaine facilitates both prefrontal cortex and medial forebrain bundle self-stimulation.
    • The mesocorticolimbic dopamine system is a potential neural substrate for these effects.
    • The specific role of dopamine in cocaine's facilitation of self-stimulation requires further investigation.