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Personalised intervention for people with depression and severe COPD
George S Alexopoulos1, Dimitris N Kiosses, Jo Anne Sirey
1Weill Cornell Medical Center, 21 Bloomingdale Road, White Plains, NY 10605, USA. gsalexop@med.cornell.edu
The British Journal of Psychiatry : the Journal of Mental Science
|February 9, 2013
Summary
A new personalized intervention for depression and chronic obstructive pulmonary disease (COPD) improved patient outcomes. This approach enhanced depression remission and reduced disability in COPD patients over 28 weeks.
Area of Science:
- Pulmonary Medicine
- Psychiatry
- Clinical Trial Research
Background:
- Chronic obstructive pulmonary disease (COPD) frequently co-occurs with depression, complicating management.
- Managing chronic illnesses requires significant patient engagement in care.
- The interplay between depression and COPD presents a significant clinical challenge.
Purpose of the Study:
- To evaluate a novel personalized intervention for depression and COPD (PID-C) aimed at improving treatment adherence.
- To compare the efficacy of PID-C against treatment as usual (TAU) in patients with comorbid depression and severe COPD.
Main Methods:
- A clinical trial (NCT00151372) involving 138 patients with major depression and severe COPD.
- Comparison of a personalized intervention (PID-C) with treatment as usual (TAU).
- Assessment of outcomes over 28 weeks and follow-up 6 months post-intervention.
Main Results:
- The PID-C group demonstrated a higher remission rate for depression compared to TAU.
- PID-C resulted in a greater reduction in depressive symptoms.
- Significant decrease in dyspnea-related disability was observed in the PID-C group.
Conclusions:
- PID-C shows promise as an effective model for managing patients with comorbid depression and COPD.
- The intervention may improve adherence and reduce symptom burden in this patient population.
- Further replication is recommended to establish PID-C as a standard care model.
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