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Updated: May 14, 2026
Micro-CT Imaging and Morphometric Analysis of Mouse Neonatal Brains
Published on: May 19, 2023
Fetal brain MRI texture analysis identifies different microstructural patterns in adequate and small for gestational
M Sanz-Cortés1, F Figueras, E Bonet-Carne
1Maternal-Fetal Medicine Department, ICGON, Hospital Clínic, Universitat de Barcelona. msanz1@clinic.ub.es
Objectives:
We tested the hypothesis whether a texture analysis (TA) algorithm applied to MRI brain images identified different patterns in small for gestational age (SGA) fetuses as compared with adequate for gestational age (AGA).
Study Design:
MRI was performed on 83 SGA and 70 AGA at 37 weeks' GA. Texture features were quantified in the frontal lobe, basal ganglia, mesencephalon, cerebellum and cingulum. A classification algorithm based on discriminative models was used to correlate texture features with clinical diagnosis.
Results:
Region of interest delineation in all areas was achieved in 61 SGA (12 vasodilated) and 52 AGA; this was the sample for TA feature extraction which allowed classifying SGA from AGA with accuracies ranging from 90.9 to 98.9% in SGA versus AGA comparison and from 93.6 to 100% in vasodilated SGA versus AGA comparison.
Conclusions:
This study demonstrates that TA can detect brain differences in SGA fetuses. This supports the existence of brain microstructural changes in SGA fetuses.
