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Related Experiment Video

Updated: May 14, 2026

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

Carbimazole-induced lupus.

Ihteshamul Haq¹, Michael D Sosin, Simon Wharton

¹Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK. i.haq@nhs.net

BMJ Case Reports

|February 9, 2013

Summary

Carbimazole, a medication for thyrotoxicosis, can induce systemic lupus erythematosus (SLE). This case highlights drug-induced SLE presenting as pleural effusion and a prothrombotic state.

Area of Science:

Internal Medicine
Rheumatology
Cardiology

Background:

Thyrotoxicosis is an endocrine disorder caused by excess thyroid hormones.
Carbimazole is an antithyroid medication used to treat hyperthyroidism.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.

Observation:

A 50-year-old female presented with dyspnea and pleuritic chest pain.
Investigations revealed sterile, exudative pleural effusion, elevated inflammatory markers, and new positive autoantibodies (ANA, anti-dsDNA, antihistone).
Echocardiography showed a left ventricular thrombus without myocardial infarction.

Findings:

The patient's thyrotoxicosis was being treated with carbimazole.
The clinical presentation and laboratory findings were consistent with drug-induced systemic lupus erythematosus (SLE).

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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

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The patient developed serositis (pleural effusion) and a proinflammatory/prothrombotic state.

Implications:

Carbimazole can induce systemic lupus erythematosus (SLE), presenting as serositis and a prothrombotic state.
Discontinuation of carbimazole led to complete resolution of the pleural effusion and symptom improvement.
This case underscores the importance of considering drug-induced autoimmune conditions in patients presenting with unexplained symptoms.