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Radical multidisciplinary approach to primary cardiac sarcomas
Oz M Shapira1, Amit Korach, Uzi Izhar
1Department of Cardiothoracic Surgery, Hebrew University, Hadassah Medical Center, Jerusalem, Israel. ozshapira@hadassah.org.il
Summary
A radical, multidisciplinary approach to primary cardiac sarcomas, including chemotherapy, surgery, and radiation, doubles patient survival. This aggressive treatment strategy is safe and effective for these rare, aggressive tumors.
Area of Science:
- Cardiology
- Surgical Oncology
- Thoracic Surgery
Background:
- Primary cardiac sarcomas are rare and aggressive tumors.
- Conventional treatment offers a median survival of 6-12 months.
- A multidisciplinary approach may improve outcomes.
Purpose of the Study:
- To evaluate the institutional experience with primary cardiac sarcomas.
- To assess the efficacy of a radical multidisciplinary treatment approach.
Main Methods:
- Established a multidisciplinary cardiac tumor program.
- Utilized pre- and postoperative chemotherapy, complete tumor resection (R0), and radiation therapy.
- Employed cardiac autotransplantation for left atrial tumors and various grafts for reconstruction.
Main Results:
- Seven patients underwent eight operations with complete tumor resection and no operative mortality.
- Median survival was 24 months, a significant improvement over conventional treatment.
- Three patients remain alive with good functional status; three died of metastatic disease.
Conclusions:
- A radical, multidisciplinary approach to cardiac sarcomas is safe.
- This strategy markedly improves patient survival, effectively doubling it.
- Complex surgical techniques and multimodality treatment are key to improved outcomes.
