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Coagulation assessment in children with diabetic ketoacidosis

Thai Hoa Tran1, Ibrahim Al-Harfi, Christopher C Harle

  • 1Critical Care Unit, Department of Paediatrics, Children's Hospital, University of Western Ontario, London, Ontario, Canada.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|February 9, 2013
PubMed

Insights

Thromboelastography did not show hypercoagulability in children with diabetic ketoacidosis (DKA). Further research is needed to explore endothelial injury

Area of Science:

  • Pediatric Critical Care
  • Pediatric Endocrinology
  • Hematology

Background:

  • Diabetic ketoacidosis (DKA) is a serious complication of diabetes in children.
  • A potential hypercoagulable state during DKA has been suspected but not fully elucidated.
  • Understanding coagulation changes in pediatric DKA is crucial for patient management.

Purpose of the Study:

  • To investigate the presence of hypercoagulability in children experiencing diabetic ketoacidosis.
  • To utilize thromboelastography to assess coagulation status in pediatric DKA patients.

Main Methods:

  • A prospective, controlled pilot study was conducted in a pediatric critical care setting.
  • Thromboelastography was performed on children (1-18 years) with DKA at admission and resolution, compared to healthy controls.
  • Standard thromboelastography parameters were analyzed.

Main Results:

  • Thromboelastography parameters in DKA patients at admission and resolution were within the normal control range.
  • No significant difference was observed in thromboelastography profiles between DKA admission and resolution.
  • While the alpha angle was higher in known diabetics, it remained within normal limits.

Conclusions:

  • Thromboelastography assays do not indicate a hypercoagulable state in children with DKA.
  • Further research is warranted to investigate the role of endothelial injury in DKA-associated hypercoagulability.
Abstract

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