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Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution
Published on: April 16, 2019
[Non-alcoholic steatohepatitis and cirrhosis in young adult patients with hypothalamic-pituitary dysfunction]
1Institut für Pathologie, Universität Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany.
Background:
In rare cases, hypothalamic-pituitary dysfunction can be associated with an extraordinarily active non-alcoholic steatohepatitis (NASH) and subsequent liver cirrhosis.
Case Report:
The two young adult patients described in this report presented with NASH together with advanced liver fibrosis and cirrhosis 5 and 19 years, respectively after resection of a craniopharyngeoma.
Conclusions:
In young patients and children with active steatohepatitis, an association with hypothalamic-pituitary dysfunction should be excluded. Especially hypothalamic-pituitary-related NASH tends to develop rapidly into liver cirrhosis.
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