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Related Experiment Video

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Using CRISPR/Cas9 Gene Editing to Investigate the Oncogenic Activity of Mutant Calreticulin in Cytokine Dependent Hematopoietic Cells

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Published on: January 5, 2018

Calreticulin and cancer.

Mohammadreza Zamanian¹, Abhi Veerakumarasivam, Syahril Abdullah

¹Genetic Medicine Research Center, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor Darul Ehsan, Malaysia.

Pathology Oncology Research : POR

|February 9, 2013

Summary

Calreticulin (CRT) is an endoplasmic reticulum protein impacting cell functions, including cancer progression. This review explores CRT's role in malignant proliferation and invasion mechanisms.

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Published on: March 10, 2023

Area of Science:

Molecular Biology
Cell Biology
Oncology

Background:

Calreticulin (CRT) is a versatile endoplasmic reticulum protein.
CRT participates in crucial cellular processes like calcium homeostasis, protein folding, and cell adhesion.
Prior research indicates CRT's involvement in various cancer types.

Purpose of the Study:

To review the multifaceted roles of Calreticulin (CRT) in cancer.
To elucidate the specific mechanisms by which CRT contributes to malignant proliferation.
To examine CRT's function in promoting cancer invasion.

Main Methods:

Literature review of existing studies on Calreticulin (CRT) and cancer.
Analysis of molecular pathways implicated in CRT-mediated cancer progression.
Synthesis of findings regarding CRT's role in invasion and metastasis.

Main Results:

Calreticulin (CRT) influences multiple stages of cancer development.
CRT can promote cell proliferation through various signaling pathways.
Evidence suggests CRT actively contributes to cancer cell invasion and metastasis.

Conclusions:

Calreticulin (CRT) is a significant factor in cancer progression and invasion.
Targeting CRT may offer potential therapeutic strategies for cancer treatment.
Further research is warranted to fully understand CRT's complex role in oncology.