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The Oral Microbiota

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Updated: May 14, 2026

Purification of a High Molecular Mass Protein in Streptococcus mutans
09:51

Purification of a High Molecular Mass Protein in Streptococcus mutans

Published on: September 14, 2019

Streptococcus mutans: a new Gram-positive paradigm?

José A Lemos1, Robert G Quivey1, Hyun Koo1

  • 1Center for Oral Biology and Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA.

Microbiology (Reading, England)
|February 9, 2013
PubMed
Summary

Streptococcus mutans, a dental pathogen, is proposed as a novel Gram-positive model organism. Its unique characteristics advance understanding of bacterial biofilms, competence, and stress responses.

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Area of Science:

  • Bacteriology
  • Microbiology
  • Genomics

Background:

  • Established bacterial model organisms like Escherichia coli and Bacillus subtilis have limitations.
  • Culturing, genetic manipulation, and safety concerns hinder research with some bacteria.
  • Model organisms are crucial for understanding closely related species.

Purpose of the Study:

  • To propose Streptococcus mutans as a novel Gram-positive model organism.
  • To highlight S. mutans' utility in advancing bacteriology research.
  • To demonstrate S. mutans' relevance for studying biofilms, competence, and stress.

Main Methods:

  • Analysis of S. mutans' lifestyle and host association.
  • Evaluation of available in vitro and in vivo experimental systems.
  • Review of existing knowledge on S. mutans' genetics, biochemistry, and physiology.

Main Results:

  • S. mutans' characteristics facilitate research on interspecies biofilms.
  • Studies on S. mutans have significantly advanced understanding of competence development.
  • S. mutans research provides insights into bacterial stress responses.

Conclusions:

  • Streptococcus mutans is a valuable model organism for Gram-positive bacteria.
  • Its unique biology, especially in host association, offers novel research avenues.
  • S. mutans aids in understanding complex bacterial behaviors relevant to human health.