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Decision Making: P-value Method01:09

Decision Making: P-value Method

The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim  is also stated. These statements can act as null and alternative hypotheses:  a null hypothesis would be a neutral statement while the alternative hypothesis can have a...
Methods of Documentation III: PIE01:21

Methods of Documentation III: PIE

Problem-intervention-evaluation (PIE) is a systematic approach to documentation used in healthcare settings for clinical decision-making and patient care planning. It is a structured approach to organizing patient data based on problems, interventions, and evaluations. Here's a breakdown of its key features and considerations:
P-value01:10

P-value

P-value is one of the most crucial concepts in statistics.
P-value stands for the probability value.  P-value is the probability that, if the null hypothesis is true, the results from another randomly selected sample will be as extreme or more extreme as the results obtained from the given sample.
A large P-value calculated from the data indicates to  not reject the null hypothesis. But a higher P-value does not mean that the null hypothesis is true. The smaller the P-value, the more unlikely...
Methods of Documentation II: POMR01:26

Methods of Documentation II: POMR

The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
pV-Diagrams01:18

pV-Diagrams

The pV diagram, which is a graph of pressure versus volume of the gas under study, is helpful in describing certain aspects of the substance. When the substance behaves like an ideal gas, the ideal gas equation describes the relationship between its pressure and volume. On a pV diagram, it is common to plot an isotherm, which is a curve showing p as a function of V with the number of molecules and the temperature fixed. Then, for an ideal gas, the product of the pressure of the gas and its...

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Related Experiment Video

Updated: May 14, 2026

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
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The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Expect p&t committees to demand more data.

Scott Kober

    Biotechnology Healthcare
    |February 9, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Recent drug withdrawals may lead to increased scrutiny of novel biologics and breakthrough therapies by formulary committees. Pharmacy and Therapeutics (P&T) members will likely increase their questioning before approving these advanced treatments.

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    Area of Science:

    • Pharmaceutical policy
    • Drug evaluation
    • Health economics

    Background:

    • High-profile drug withdrawals have raised concerns regarding the safety and efficacy of novel therapeutics.
    • Formulary committees play a critical role in drug approval and access decisions.

    Purpose of the Study:

    • To assess the potential impact of drug withdrawals on the perception and approval process of biologics and breakthrough therapies by Pharmacy and Therapeutics (P&T) committees.
    • To understand how P&T members' questioning and scrutiny might change for innovative drug products.

    Main Methods:

    • Qualitative analysis of formulary committee member sentiment.
    • Review of recent drug withdrawal data and its correlation with P&T meeting minutes.
    • Expert interviews with formulary decision-makers.

    Main Results:

    • Formulary committees are expected to exhibit increased skepticism towards biologics and breakthrough therapies following significant drug withdrawals.
    • P&T members are likely to pose more in-depth questions regarding clinical evidence, safety profiles, and comparative effectiveness.

    Conclusions:

    • Past drug withdrawals may necessitate a more rigorous and cautious approach by P&T committees when evaluating novel and high-impact medications.
    • Future drug development and approval processes may need to address heightened scrutiny for innovative therapies.