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Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

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An uncommon but lethal poisoning - Amitraz.

Joydeep Chakraborty¹, Shivashankara Kaniyoor Nagri, Amit Narayan Gupta

¹Assistant Professor, Department of Medicine, Kasturba Medical College, Manipal-576104, India.

The Australasian Medical Journal

|February 9, 2013

Summary

Amitraz, an ectoparasiticide, can cause severe poisoning in humans, mimicking organophosphate toxicity. Prompt supportive care leads to full recovery, even with unusual symptoms like mydriasis.

Keywords:

Amitraz Poisoning α2 adrenergic agonist

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Area of Science:

Veterinary Pharmacology
Human Toxicology
Emergency Medicine

Background:

Amitraz is widely used in veterinary medicine for ectoparasite control in cattle.
Human toxicity from Amitraz is uncommon but can mimic organophosphate poisoning.
Limited human toxicological data exists for Amitraz.

Observation:

A case of suicidal Amitraz ingestion presented with coma, respiratory depression, and bradycardia.
The patient exhibited mydriasis, an atypical finding compared to previously reported miosis.
Recovery was complete within 24 hours with supportive management.

Findings:

Amitraz poisoning can lead to life-threatening central nervous system and cardiovascular effects.
Clinical presentation may vary, including atypical pupillary responses (mydriasis).
Early recognition and supportive care are crucial for favorable outcomes.

Implications:

Highlights the potential for severe human toxicity from veterinary Amitraz exposure.
Emphasizes the need for increased awareness among clinicians regarding Amitraz poisoning.
Underscores the importance of supportive measures in managing Amitraz toxicity.