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Updated: May 14, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
[Assessment of exposure to cancerogenic aromatic hydrocarbon during controlled-access highways management activities]
I Martinotti1, A M Cirla, D Cottica
1Divisione Tossicologica CIMAL (DITOC), Centro Italiano Medicina Ambiente Lavoro (Gruppo CIMAL), Via Friuli n.61 20135 Milano. irene.martinotti@gruppocimal.it
Abstract:
The purpose of this study was an integrated assessment of exposure to benzene and Polycyclic Aromatic Hydrocarbons (PAH) in 29 workers employed to manage a controlled-access highways. A campaign was performed in summertime by environmental monitoring (active and passive airborne personal sampler), as well as by biological monitoring (urine samples of the beginning and of the end of daily shift, baseline after two days of vacation). The measured environmental levels did not differ from background environmental concentrations found in a metropolitan area (i.e. benzo[a]pyrene < 1 ng/m3; benzene < 5 mcg/m3), and the results of biological monitoring were in agreement and were compatible with extra-professional habits of the investigated subjects (1-hydroxipyrene 50-990 ng/g creatinine; unmetabolized benzene 15-2010 ng/I; t-t muconic acid < 4-222 mcg/g creatinine).
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