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Updated: May 14, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
[Hospital-acquired pneumonia caused by biological pathogens]
1Military Institute of Medicine in Warsaw, Central Clinical Hospital of the Ministry of National Defense, Department of Internal Medicine, Pneumonology and Allergology. sfrom@wim.mil.pl
Abstract:
Hospital-acquired pneumonia (HAP) is recognized when the clinical and radiological symptoms appear in the 48-72 hours from the admission to the hospital or in the case of pneumonia during the mechanical respiration after 72 hours of the patient's intubation. The frequency of HAP placed between 5 to 15 per 1000 patients undergoing hospital treatment. The appearance of clinical symptoms: high fever, cough with expelling of purulent sputum, an increased number of breaths or dyspnoe and the occurrence of inflammation's morphological markers and the presence of new changes in the radiography (or severity seen earlier) confirms the diagnosis. Difficulties arise during the treatment of pneumonia caused by several strains of bacteria or flora which are resistant to available antibiotics. This is the reasons of high mortality among patients with HAP, reaching above 35%.
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