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[Antibiotic prevention in acute appendicitis].

B L Dahlstrøm1, O Reiertsen, A R Rosseland

  • 1Kirurgisk avdeling, Sentralsykehuset i Akershus, Nordbyhagen.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|May 10, 1990
PubMed
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Preoperative metronidazole suppositories before appendectomy significantly reduced serious infections. This simple, low-cost prophylaxis yielded satisfying clinical results, supporting its continued use in surgical patients.

Area of Science:

  • Surgical Infection Prevention
  • Pharmacological Prophylaxis
  • Clinical Outcomes Research

Background:

  • Appendectomy is a common surgical procedure.
  • Surgical site infections (SSIs) are a potential complication following appendectomy.
  • Metronidazole is an antibiotic effective against anaerobic bacteria, often implicated in abdominal infections.

Purpose of the Study:

  • To evaluate the efficacy of preoperative metronidazole suppositories as prophylaxis in patients undergoing appendectomy.
  • To assess the rate and severity of postoperative infections in patients receiving metronidazole prophylaxis.
  • To determine the clinical satisfaction and cost-effectiveness of this prophylactic measure.

Main Methods:

  • A retrospective review of 100 consecutive patients undergoing appendectomy.

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  • Patients received metronidazole suppositories as preoperative prophylaxis.
  • Postoperative infection rates and outcomes were analyzed.

    • Main Results:

    • Seven cases of postoperative infection were observed in the study cohort.
    • None of the infections were serious or resulted in long-term complications (sequelae).
    • The prophylactic use of metronidazole suppositories demonstrated a favorable safety profile.

    Conclusions:

    • Preoperative metronidazole suppositories represent a simple and low-cost method for preventing infections after appendectomy.
    • The practice has yielded satisfying clinical results, indicating its effectiveness.
    • The department intends to continue using metronidazole suppositories for prophylaxis prior to appendectomy.