Related Experiment Video

Updated: May 14, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

The association between urinary tract infection and idiopathic hypercalciuria in children

Hikmet Tekin Nacaroglu1, Gülay Demircin, Mehmet Bülbül

  • 1Department of Pediatric Nephrology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey. tekin212@gmail.com

Renal Failure
|February 12, 2013
PubMed

Insights

Idiopathic hypercalciuria (IHC) is a risk factor for urinary tract infections (UTIs) in children. Investigating IHC is crucial, especially in children with a family history of kidney stones and related symptoms.

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Clinical Research

Background:

  • Urinary tract infections (UTIs) are common in children.
  • Identifying risk factors is key for UTI prevention.
  • The association between UTIs and idiopathic hypercalciuria (IHC) requires further investigation.

Purpose of the Study:

  • To evaluate the association between urinary tract infections (UTIs) and idiopathic hypercalciuria (IHC) in pediatric patients.
  • To determine if IHC is a significant risk factor for UTIs in children.

Main Methods:

  • A cohort of 224 children (1 month to 16 years) diagnosed with UTI was assessed.
  • Urinary calcium excretion was measured using calcium/creatinine ratios and daily calcium excretion.
  • Diagnostic criteria for IHC included specific urinary calcium/creatinine ratios or daily calcium excretion levels.

Main Results:

  • Idiopathic hypercalciuria (IHC) was identified in 16.7% of children with UTIs.
  • Children with IHC and UTI were more likely to have a family history of urolithiasis, parental consanguinity, abdominal pain, loss of appetite, and discomfort.
  • No significant association was found between IHC and UTI recurrence, vesicoureteral reflux, renal scarring, or overall prognosis.

Conclusions:

  • Idiopathic hypercalciuria (IHC) should be considered a potential risk factor for pediatric urinary tract infections (UTIs).
  • Investigation for IHC is recommended in children with a family history of urinary stones or suggestive clinical symptoms.
  • Early identification and management of IHC may aid in UTI prevention strategies for children.
Abstract

More Related Videos

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection06:05

Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection

Published on: October 12, 2017

Related Concept Videos

Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...