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NAT2 sequence polymorphisms and acetylation profiles in Indians.

Naazneen Khan1, Veena Pande, Aparup Das

  • 1Evolutionary Genomics & Bioinformatics Laboratory, Division of Genomics & Bioinformatics, National Institute of Malaria Research, New Delhi, India.

Pharmacogenomics
|February 12, 2013
PubMed
Summary
This summary is machine-generated.

Indian acetylation profiles reveal distinct slow and fast acetylator phenotypes, correlating with historical diets. This study characterized the N-acetyltransferase 2 (NAT2) gene in 250 Indians, finding genetic affinities with African populations.

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Area of Science:

  • Pharmacogenetics
  • Human genetics
  • Population genetics

Background:

  • The N-acetyltransferase 2 (NAT2) gene is crucial for drug metabolism, influencing individual responses.
  • NAT2 genetic variations define individuals as either slow or fast acetylators.
  • Limited data exists on acetylation profiles within the diverse Indian population.

Purpose of the Study:

  • To characterize the acetylation profiles of diverse Indian populations.
  • To investigate the distribution of NAT2 gene variations across India.
  • To explore the correlation between NAT2 phenotypes and historical factors.

Main Methods:

  • Sequencing of the 873 bp NAT2 coding region in 250 Indian individuals.
  • Comprehensive sampling across India, including tribal populations.
  • Phylogenetic analysis using neighbor-joining methods.

Main Results:

  • Identification of 35 NAT2 alleles, resulting in two distinct acetylator phenotypes (slow and fast) in nearly equal proportions.
  • Slow acetylator alleles showed high differentiation, while fast acetylator alleles were fewer but more frequent.
  • Phylogenetic analysis revealed Indians and Africans clustered together, suggesting shared genetic affinities.

Conclusions:

  • The distribution of NAT2 acetylation phenotypes in India correlates with historical dietary patterns.
  • Genetic similarities observed between Indian and African populations based on NAT2 polymorphisms.
  • This study provides valuable insights into the pharmacogenetic landscape of India.