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Updated: May 14, 2026

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
Separation of piracetam derivatives on polysaccharide-based chiral stationary phases
H Kažoka1, O Koliškina, G Veinberg
1Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, LV-1006, Riga, Latvia. helena@osi.lv
Abstract:
High-performance liquid chromatography was used for the enantiomeric separation of two chiral piracetam derivatives. The suitability of six commercially available polysaccharide-based chiral stationary phases (CSPs) under normal phase mode for direct enantioseparation has been investigated. The influence of the CSPs as well the nature and content of an alcoholic modifier in the mobile phase on separation and elution order was studied. It was established that CSP Lux Amylose-2 shows high chiral recognition ability towards 4-phenylsubstituted piracetam derivatives.
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