Application for tacrolimus ointment in treating refractory inflammatory ocular surface diseases.

Area of Science:

• Ophthalmology
• Immunology
• Dermatology

Background:

• Refractory inflammatory ocular surface diseases pose significant treatment challenges.
• Steroid therapy is often used but can lead to complications and dependence.

Purpose of the Study:

• To evaluate the therapeutic efficacy of topical tacrolimus ointment.
• To assess its role in managing refractory inflammatory ocular surface diseases.

Main Methods:

• Retrospective case series of 12 patients with severe ocular surface diseases.
• Topical 0.02% tacrolimus ointment applied 1-3 times daily for up to 31 months.
• Evaluation included clinical findings, intraocular pressure, and need for steroid therapy.

Main Results:

• Tacrolimus demonstrated immunosuppressive effects, particularly in scleritis and Mooren ulcer, reducing corneoscleral melting and hyperemia.
• It helped suppress inflammatory relapse in chronic cicatrizing conjunctivitis during steroid tapering.
• No adverse side effects were observed during the treatment period.

Conclusions:

• Topical tacrolimus is effective for controlling refractory inflammatory ocular surface diseases.
• It reduces the need for steroid use and prevents inflammation recurrence.
• Tacrolimus offers a safe and beneficial alternative for managing these challenging conditions.