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Related Experiment Video

Updated: May 14, 2026

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Published on: October 9, 2018

Ex Utero Intrapartum Therapy.

Julie S Moldenhauer¹

¹The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4399, USA. moldenhauerj@email.chop.edu

Seminars in Pediatric Surgery

|February 12, 2013

Summary

The Ex Utero Intrapartum Therapy (EXIT) procedure provides a critical airway management solution for newborns facing respiratory distress at birth. This technique allows for life-saving interventions while maintaining placental support during delivery.

Area of Science:

Fetal Surgery
Neonatal Resuscitation
Anesthesiology

Background:

The Ex Utero Intrapartum Therapy (EXIT) procedure was developed for fetal airway management during delivery.
Its application has broadened to include various neonatal airway compromise conditions and anticipated difficult resuscitations.

Purpose of the Study:

To detail the expanded indications and methodology of the EXIT procedure.
To highlight its role in facilitating urgent neonatal surgical interventions.

Main Methods:

Maintaining uteroplacental blood flow and gas exchange via inhalational anesthetics.
Utilizing partial fetal delivery with amnioinfusion for uterine distension.
Performing interventions during placental bypass.

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Main Results:

The EXIT procedure allows crucial time for procedures like bronchoscopy, laryngoscopy, intubation, tracheostomy, ECMO cannulation, and mass resections.
It enables these interventions in a controlled setting, preventing potential delivery catastrophes.

Conclusions:

The EXIT procedure is a vital tool for managing complex neonatal airway issues at birth.
It significantly improves outcomes for fetuses requiring immediate surgical intervention upon delivery.