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Updated: May 14, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
[Non pharmacological treatment for bipolar disorder]
Christine Mirabel-Sarron1, Raphaël Giachetti
1Université Paris 5 René Descartes, CMME Service de Monsieur le Professeur Rouillon, Centre Hospitalier Sainte Anne, 100 rue de la Santé, Paris. c.sarron@ch-sainte-anne.fr
Abstract:
Bipolar disorder is a chronic and recurring disorder associated with significant psychosocial impairment. A number of psychosocial interventions have been developed to address impairment. The consensus makes mood stabilizer the treatment of bipolar disorder. However, numerous patients are not in complete remission despite a controlled observance. Every patient can follow a psycho educational program. What this paper adds. The review identifies that a range of interventions have demonstrated efficacy in extended periods of euthymia, improved social and occupational functioning and alleviation of subsyndromal symptoms. Adjunctive, short-term psychotherapies have been shown to offer fairly consistent benefits to bipolar disorder patients. Cognitive-behavioural therapy, family-focused therapy, and psychoeducation offer the most robust efficacy in regard to relapse prevention. The most complex situations including comorbidities can be helped by behavioral and cognitive therapy for bipolar disorder. Evaluations emphasize positive impact. The psychosocial interventions reviewed provide mental health nurses with evidence-based approaches to improving mental health care for patients with bipolar disorder. There is a need for mental health nurses to conduct high quality trials of the clinical effectiveness of these interventions.
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