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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment
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Published on: July 26, 2024

Frailty in elderly people.

Andrew Clegg1, John Young, Steve Iliffe

  • 1Academic Unit of Elderly Care and Rehabilitation, University of Leeds, Leeds, UK. a.p.clegg@leeds.ac.uk

Lancet (London, England)
|February 12, 2013
PubMed
Summary

Frailty, a vulnerability from aging, results from cumulative physiological decline. Early detection methods are crucial for better care and treatment selection in older adults.

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Frailty Assessment in an Aging Mouse Model
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Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

Area of Science:

  • Gerontology
  • Public Health
  • Clinical Medicine

Background:

  • Frailty is a significant challenge in population aging, characterized by vulnerability and poor homeostasis after stressors.
  • It stems from a lifetime of cumulative physiological decline, depleting reserves and leading to adverse health outcomes.
  • Current frailty models enable epidemiological studies but efficient clinical detection methods are lacking.

Purpose of the Study:

  • To highlight the need for more efficient frailty detection methods in routine clinical practice.
  • To emphasize the importance of primary care-focused frailty assessment tools.
  • To advocate for a shift towards goal-directed care for frail elderly individuals.

Main Methods:

  • The abstract discusses the development of valid frailty models in landmark studies.
  • It references epidemiological investigations utilizing these models.
  • It emphasizes the need for developing new, efficient detection methods.

Main Results:

  • Landmark studies have established valid models for frailty.
  • Epidemiological research demonstrates a clear association between frailty and adverse health outcomes.
  • The need for improved clinical detection and severity measurement is identified.

Conclusions:

  • Frailty is a critical issue in aging populations, impacting health status and outcomes.
  • Developing efficient frailty detection methods for primary care is essential.
  • Improved frailty assessment will facilitate appropriate treatment selection and goal-directed care for the elderly.