Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Procedure-Only Transfer Pathway - An Alternative to Standard Interhospital Transfer to Address Time-Sensitive Procedural Needs.

NEJM catalyst innovations in care delivery·2026
Same author

The neuropeptide neuromedin U receptor NMUR-1 buffers insulin receptor signaling in bacteria-dependent C. elegans survival.

PLoS genetics·2026
Same author

An epifluorescence microscope design for naturalistic behavior and cellular activity in freely moving Caenorhabditis elegans.

Nature communications·2026
Same author

Reframing healthcare workplace violence: Compassion without complacency.

Journal of hospital medicine·2026
Same author

Perspectives on increasing corporate ownership and unionization in hospital medicine: An exploratory mixed methods study.

Journal of hospital medicine·2026
Same author

The impact of rearing environment on C. elegans: phenotypic, transcriptomic and intergenerational responses to 3D enriched habitats.

Biology open·2026

Related Experiment Video

Updated: May 14, 2026

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans.

Zhunan Chen1, Michael Hendricks, Astrid Cornils

  • 1Department of Organismic and Evolutionary Biology, The Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.

Neuron
|February 12, 2013
PubMed
Summary

Two insulin-like peptides (ILPs) in C. elegans control aversive olfactory learning. ILP INS-6 enables learning by regulating ILP INS-7, revealing a novel ILP-to-ILP pathway in neural plasticity.

More Related Videos

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay
06:45

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay

Published on: July 26, 2017

C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays
09:58

C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays

Published on: March 11, 2011

Related Experiment Videos

Last Updated: May 14, 2026

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay
06:45

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay

Published on: July 26, 2017

C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays
09:58

C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays

Published on: March 11, 2011

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Insulin/insulin-like peptides (ILPs) are crucial for physiological processes, including neural plasticity.
  • The precise cellular and circuit mechanisms by which ILPs influence learning are not fully understood.

Purpose of the Study:

  • To investigate the roles of two specific ILPs, INS-6 and INS-7, in aversive olfactory learning in C. elegans.
  • To elucidate the cellular and circuit mechanisms underlying ILP-mediated learning.

Main Methods:

  • Characterization of two ILPs, ins-6 and ins-7, in C. elegans.
  • Analysis of gene transcription and neuronal activity.
  • Investigation of the roles of ASI, URX, and RIA neurons in olfactory learning.

Main Results:

  • The ILP ins-6, acting from ASI neurons, promotes learning by repressing ins-7 transcription in URX neurons.
  • Elevated levels of URX-derived INS-7 disrupt learning by antagonizing the DAF-2 receptor in RIA neurons.
  • Both increased URX-INS-7 and loss of INS-6 impair learning and alter RIA neuronal properties.

Conclusions:

  • A novel "ILP-to-ILP" signaling pathway regulates olfactory learning.
  • This pathway connects environment-sensing neurons (ASI, URX) to a key learning circuit neuron (RIA).
  • The pathway modulates RIA neuronal activity, impacting olfactory plasticity.