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5-Azacytidine induces early stage apoptosis and promotes in vitro maturation by changing chromosomal construction in

F Y Zhao1, C P Shao, Y Li

  • 1State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, People's Republic of China. jldxzfy004950@126.com

Reproductive Toxicology (Elmsford, N.Y.)
|February 12, 2013
PubMed

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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