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Mini-review: Foldosome regulation of androgen receptor action in prostate cancer

Laia Querol Cano1, Derek N Lavery, Charlotte L Bevan

  • 1Department of Surgery and Cancer, Imperial Centre for Translational and Experimental Medicine, Hammersmith Hospital Campus, Imperial College London, London, United Kingdom.

Molecular and Cellular Endocrinology
|February 12, 2013
PubMed

Insights

The foldosome, crucial for steroid hormone receptor function, is increasingly recognized for roles beyond the cytosol. Its components are promising therapeutic targets and biomarkers for prostate cancer.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Steroid hormone receptors are vital transcription factors regulating numerous physiological processes.
  • The foldosome, comprising chaperone proteins, is essential for ligand binding to these receptors.
  • Recent findings reveal foldosome involvement in nuclear translocation and gene expression, expanding its known functions.

Purpose of the Study:

  • To review the impact of the foldosome on androgen receptor signaling.
  • To explore the potential of foldosome components as biomarkers and therapeutic targets in prostate cancer.

Main Methods:

  • Literature review of current research on foldosome components and steroid hormone receptors.
  • Focus on studies investigating androgen receptor signaling pathways.
  • Analysis of data linking foldosome dysregulation to cancer development.

Main Results:

  • The foldosome's role extends to nuclear translocation and target gene expression, not just ligand binding.
  • Dysregulation of foldosome components is implicated in various cancers, notably prostate cancer.
  • Androgen receptor signaling, a key target in prostate cancer, is significantly influenced by the foldosome.

Conclusions:

  • The foldosome is a critical regulator of androgen receptor signaling.
  • Foldosome components represent attractive therapeutic targets and potential biomarkers for prostate cancer management.

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