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CrossTope: a curate repository of 3D structures of immunogenic peptide: MHC complexes
Marialva Sinigaglia1, Dinler Amaral Antunes, Maurício Menegatti Rigo
1NBLI - Núcleo de Bioinformática do Laboratório de Imunogenética, Department of Genetics, Universidade Federal do Rio Grande do Sul, 9500 Bento Gonçalves Avenue, Bldg 43323, Rm 225, 91501-970 Porto Alegre, RS, Brazil.
Abstract:
The CrossTope is a highly curate repository of three-dimensional structures of peptide:major histocompatibility complex (MHC) class I complexes (pMHC-I). The complexes hosted by this databank were obtained in protein databases and by large-scale in silico construction of pMHC-I structures, using a new approach developed by our group. At this moment, the database contains 182 'non-redundant' pMHC-I complexes from two human and two murine alleles. A web server provides interface for database query. The user can download (i) structure coordinate files and (ii) topological and charges distribution maps images from the T-cell receptor-interacting surface of pMHC-I complexes. The retrieved structures and maps can be used to cluster similar epitopes in cross-reactivity approaches, to analyse viral escape mutations in a structural level or even to improve the immunogenicity of tumour antigens. Database URL: http://www.crosstope.com.br.
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