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Related Experiment Videos

Fluoride-induced fractures: relation to osteogenic effect.

T A Bayley1, J E Harrison, T M Murray

  • 1St. Joseph's Health Centre, Toronto General Hospital, Ontario, Canada.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|March 1, 1990
PubMed
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Sodium fluoride (NaF) therapy may increase hip fracture risk, even with increased bone mass. Bone fluoride levels and age were significant factors in fracture occurrence in patients treated for osteoporosis.

Area of Science:

  • Endocrinology
  • Orthopedics
  • Gerontology
  • Pharmacology

Background:

  • Sodium fluoride (NaF) is used to treat osteoporosis by increasing bone mineral density.
  • However, the potential skeletal risks associated with NaF therapy, such as fracture induction, require further investigation.
  • Understanding the relationship between NaF, bone fluoride levels, and fracture incidence is crucial for patient safety.

Purpose of the Study:

  • To investigate the potential role of fluoride therapy in inducing fractures.
  • To examine the correlation between bone fluoride levels, bone mineral mass, and the occurrence of hip and lower extremity fractures.
  • To assess the risk factors associated with fluoride-induced fractures in patients receiving NaF treatment.

Main Methods:

Related Experiment Videos

  • A study involving 61 patients treated with sodium fluoride (NaF), calcium, and vitamin D.
  • Bone mineral mass was measured using neutron activation, expressed as a calcium bone index (CaBI).
  • Bone fluoride retention and patient age were analyzed in relation to fracture incidence, particularly hip fractures.

Main Results:

  • Seven patients experienced 10 upper femur fractures; 5 were stress fractures.
  • Patients with hip fractures showed significantly higher bone fluoride retention (30 mg/g Ca vs. 23.9 mg/g Ca) and were older (73.1 vs. 64.2 years).
  • Femur fractures correlated significantly with bone fluoride and age, with bone fluoride remaining significant after controlling for age.

Conclusions:

  • Fluoride therapy, specifically NaF, may be implicated in the pathogenesis of hip fractures.
  • Hip fractures can occur despite a marked increase in bone mass during fluoride treatment.
  • The study suggests a significant association between elevated bone fluoride levels and hip fracture risk.