Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

5.2K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

5.1K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.1K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

610
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
610
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

8.0K
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
8.0K
Humoral Immune Responses01:36

Humoral Immune Responses

84.0K
Overview
84.0K
The Apoplast and Symplast01:46

The Apoplast and Symplast

54.1K
Plant growth depends on its ability to take up water and dissolved minerals from the soil. The root system of every plant is equipped with the necessary tissues to facilitate the entry of water and solutes. The plant tissues involved in the transport of water and minerals have two major compartments - the apoplast and the symplast. The apoplast includes everything outside the plasma membrane of living cells and consists of cell walls, extracellular spaces, xylem, phloem, and tracheids. The...
54.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cyclin E drives human keratinocyte growth into differentiation.

Oncogene·2012
Same author

Cell type-dependent control of NF-Y activity by TGF-beta.

Oncogene·2006
Same author

Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain.

The EMBO journal·2001
Same author

Terminal minihelix, a novel RNA motif that directs polymerase III transcripts to the cell cytoplasm. Terminal minihelix and RNA export.

The Journal of biological chemistry·2001
Same author

Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1.

Molecular and cellular biology·2001
Same author

mRNA localization by a 145-nucleotide region of the c-fos 3'--untranslated region. Links to translation but not stability.

The Journal of biological chemistry·2001
Same journal

SRD5A3-mediated aberrant N-glycosylation of SCARA5 promotes ferroptosis in lung adenocarcinoma.

Oncogene·2026
Same journal

Aberrant splicing in human cancer shows possible functional impact on transcription factors.

Oncogene·2026
Same journal

The crosstalk between RNA m6A modification and protein lactylation: emerging insights into tumor progression.

Oncogene·2026
Same journal

Correction: Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway.

Oncogene·2026
Same journal

Amphiregulin-mediated EGFR activation drives both intrinsic and acquired resistance to KRAS G12C inhibitors in KRAS G12C-mutant non-small cell lung cancer.

Oncogene·2026
Same journal

Histone lactylation-driven IGF2BP3 promotes intrahepatic cholangiocarcinoma progression via SPP1/CD44-dependent macrophage polarization.

Oncogene·2026
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
07:05

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: February 23, 2024

3.8K

To be or not to be a proliferation marker?

J M Blanchard1

  • 11] Institut de Génétique Moléculaire de Montpellier, CNRS, Montpellier, France [2] Université Montpellier 2, Montpellier, France [3] Université Montpellier 1, Montpellier, France.

Oncogene
|February 12, 2013
PubMed
Summary
This summary is machine-generated.

Cancer proliferation markers like c-Myc and cyclin A2 have dual roles. Overexpressing c-Myc boosts local growth but hinders metastasis, while reducing cyclin A2 increases cancer cell motility.

More Related Videos

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

3.7K
Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage
12:59

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage

Published on: February 15, 2020

6.7K

Related Experiment Videos

Last Updated: Feb 8, 2026

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
07:05

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: February 23, 2024

3.8K
Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

3.7K
Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage
12:59

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage

Published on: February 15, 2020

6.7K

Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Proliferation markers are crucial in cancer research.
  • Established markers like c-Myc and cyclin A2 are increasingly recognized for complex roles.
  • Their functions in regulating both tumor growth and metastasis are under investigation.

Purpose of the Study:

  • To explore the paradoxical roles of c-Myc and cyclin A2 in cancer.
  • To understand how these markers influence cancer cell proliferation and metastasis.

Main Methods:

  • Review of recent reports on c-Myc and cyclin A2 functions.
  • Analysis of their impact on cancer cell proliferation, invasiveness, and motility.

Main Results:

  • Overexpression of c-Myc stimulates local cancer cell proliferation.
  • c-Myc overexpression inhibits cancer cell invasiveness.
  • Downregulation of cyclin A2 increases the motility of cancer cells.

Conclusions:

  • c-Myc and cyclin A2 exhibit ambiguous functions in cancer progression.
  • These markers play complex roles in balancing proliferation and metastasis.
  • Further research is needed to fully elucidate their therapeutic potential.