Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Cross-reactivity00:42

Cross-reactivity

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation of a Large Language Model Enhanced Frailty Index.

Journal of medical systems·2026
Same author

Precision Grounding: augmenting large language models with evidence-based databases for trustworthy genetic variant summarization.

International journal of medical informatics·2026
Same author

Interactive active learning for literature screening: finetuning GPT with DeepSeek reasoning for cross-domain generalization.

Journal of the American Medical Informatics Association : JAMIA·2026
Same author

Linguistic Effects of Ambient AI on Clinical Documentation: A Matched Pre-Post Study.

medRxiv : the preprint server for health sciences·2026
Same author

Prescription Real-Time Benefit Tools: Clinicians Receive Frequent Alerts Yet Rarely Accept The Suggested Changes.

Health affairs (Project Hope)·2026
Same author

Natural language processing for scalable feature engineering and ultra-high-dimensional confounding adjustment in healthcare database studies.

Journal of biomedical informatics·2025
Same journal

Extending the fundamental theorem of biomedical informatics: a proposal and illustrative examples.

Journal of the American Medical Informatics Association : JAMIA·2026
Same journal

Human factors methods for designing safe health information technology: what do the experts think?

Journal of the American Medical Informatics Association : JAMIA·2026
Same journal

Equity-by-design for socially assistive robots as digital health tools.

Journal of the American Medical Informatics Association : JAMIA·2026
Same journal

Orchestrator multi-agent clinical decision support system for secondary headache diagnosis in primary care.

Journal of the American Medical Informatics Association : JAMIA·2026
Same journal

CUI-Curate: a GraphRAG-based framework for automated clinical concept curation for NLP applications.

Journal of the American Medical Informatics Association : JAMIA·2026
Same journal

Malfunctions in distributed clinical decision support: 3 cases from a multi‑component clinical decision support system.

Journal of the American Medical Informatics Association : JAMIA·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

Evaluating standard terminologies for encoding allergy information.

Foster R Goss1, Li Zhou, Joseph M Plasek

  • 1Clinical Informatics Research & Development, Partners HealthCare System, Inc., Wellesley, Massachusetts, USA.

Journal of the American Medical Informatics Association : JAMIA
|February 12, 2013
PubMed
Summary
This summary is machine-generated.

Comparing standard terminologies for allergy documentation, this study found that Systemized Nomenclature of Medical Clinical Terms (SNOMED CT) and RxNorm together offer the best coverage for representing diverse allergy information and adverse reactions.

Keywords:
AllergyDrug IntoleranceHypersensitivityStandardsTerminologyVocabulary, Controlled

More Related Videos

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Related Experiment Videos

Last Updated: May 14, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)

Published on: April 21, 2019

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Area of Science:

  • Medical Informatics
  • Clinical Terminology
  • Patient Safety

Background:

  • Accurate allergy documentation is crucial for patient safety.
  • Standardized terminologies are needed for effective allergy information exchange.
  • Existing terminologies vary in their ability to represent complex allergy data.

Purpose of the Study:

  • To analyze and compare standard terminologies for representing allergy information.
  • To evaluate content coverage and desirable characteristics of selected terminologies.
  • To identify optimal terminology solutions for allergy encoding.

Main Methods:

  • Qualitative and quantitative analyses of five terminologies: SNOMED CT, NDF-RT, MedDRA, UNII, and RxNorm.
  • Evaluation of characteristics like content coverage, concept orientation, and maintainability.
  • Comparison of concept coverage for food, drug, environmental allergens, and adverse reactions.

Main Results:

  • SNOMED CT excelled in desirable characteristics; RxNorm led in drug allergen coverage; UNII led in food/environmental allergen coverage.
  • SNOMED CT and NDF-RT showed high coverage for descriptive allergy concepts and adverse reactions.
  • SNOMED CT uniquely represented 'no known allergies'; RxNorm and SNOMED CT combined offer broad coverage.

Conclusions:

  • Encoding patient allergies requires comprehensive terminology support.
  • No single terminology perfectly captures all allergy aspects.
  • A combination of SNOMED CT and RxNorm is recommended for robust allergy documentation.