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Negative endocrine control system for inflammation in rats.

V I Stenberg1, M G Bouley, B M Katz

  • 1Department of Chemistry, The University of North Dakota, Grand Forks 58202.

Agents and Actions
|March 1, 1990
PubMed
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The body releases corticosterone, a stress hormone, in response to inflammation and injection stress. This hormone release helps suppress inflammatory responses, acting as a natural feedback mechanism.

Area of Science:

  • Endocrinology
  • Immunology
  • Pharmacology

Background:

  • Inflammatory processes can be modulated by endogenous mechanisms, notably the release of adrenocorticosteroid hormones.
  • The hypothalamus-pituitary-adrenal (HPA) axis plays a crucial role in mediating these hormonal responses.

Purpose of the Study:

  • To investigate the relationship between carrageenan-induced edema development in rats and plasma corticosterone release.
  • To understand the temporal dynamics of corticosterone release during an inflammatory response.

Main Methods:

  • Carrageenan was injected into the hindlimb of rats to induce edema.
  • Plasma corticosterone levels were measured at various time points post-injection.
  • Hypophysectomy was performed in some rats to assess the role of the HPA axis.

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Main Results:

  • Carrageenan injection induced a biphasic increase in plasma corticosterone levels.
  • The initial rapid increase was attributed to injection stress, while the later, sustained increase correlated with the inflammatory response.
  • Impaired HPA axis function (hypophysectomy) led to more severe and prolonged edema.

Conclusions:

  • Adrenocorticosteroid hormones, specifically corticosterone, are released in response to both the stress of injection and the inflammatory process itself.
  • The release of adrenocorticosteroids serves as a crucial negative feedback mechanism to suppress inflammation.