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Updated: May 14, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
Syphilis: a reversible cause of nephrotic syndrome
M Louis Handoko1, Marjolijn Duijvestein, Cornelis G Scheepstra
1Department of Internal Medicine/Nephrology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands. ml.handoko@vumc.nl
Abstract:
A patient in his late 30s presented with symptoms consistent with a nephrotic syndrome. Renal biopsy revealed membranous nephropathy. He also mentioned a spontaneous resolving 'rash' at his glans penis after unprotected intercourse. Therefore, he was tested for sexually transmitted diseases as a possible underlying cause of his nephrotic syndrome. Serology for syphilis was positive with high titres. After a single penicillin injection, there was fast and complete clinical recovery.
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