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Site Directed Spin Labeling and EPR Spectroscopic Studies of Pentameric Ligand-Gated Ion Channels
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Published on: July 4, 2016

The structural mechanism of the Cys-loop receptor desensitization

Jianliang Zhang1, Fenqin Xue, Yujun Liu

  • 1Beijing Institute of Brain Disorders, Capital Medical University, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Center of Neural Regeneration and Repair, Beijing Key Laboratory of Brain Major Disorders-State Key Lab Incubation Base, Beijing Neuroscience Disciplines, #10 Xitoutiao, Youanmenwai, Beijing, 100069, China. jlzhang@ccmu.edu.cn

Molecular Neurobiology
|February 12, 2013
PubMed
Summary

Cys-loop receptors desensitize through uncoupling between domains, impacting neuronal communication. Recent research reveals multiple receptor parts contribute to this crucial process.

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