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Related Concept Videos

Drug Product Stability01:16

Drug Product Stability

The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
Drug Concentration Versus Time Correlation01:15

Drug Concentration Versus Time Correlation

The plasma drug concentration-time curve is a crucial tool in pharmacokinetics, representing the drug's concentration in plasma at different time intervals post-administration. This curve illustrates the drug's journey from absorption into the systemic circulation, distribution to body tissues, and eventual elimination through excretion or biotransformation.
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the lowest drug...
Actuarial Approach01:20

Actuarial Approach

The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Stability of Equilibrium Configuration01:23

Stability of Equilibrium Configuration

Understanding the stability of equilibrium configurations is a fundamental part of mechanical engineering. In any system, there are three distinct types of equilibrium: stable, neutral, and unstable.
A stable equilibrium occurs when a system tends to return to its original position when given a small displacement, and the potential energy is at its minimum. An example of a stable equilibrium is when a cantilever beam is fixed at one end and a weight is attached to the other end. If the weight...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Steady State Concentration01:05

Steady State Concentration

A steady state refers to the level of a drug in the body once it has reached an equilibrium between administration and elimination. It represents the point at which the drug administration rate equals the drug elimination rate, resulting in a relatively constant concentration in the body over time. The dynamic equilibrium is crucial to ensure the drug's effectiveness with minimal risk of toxicity.
Most drugs are administered in repeated doses at fixed intervals or through continuous intravenous...

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Related Experiment Video

Updated: May 14, 2026

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods
06:12

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods

Published on: April 14, 2023

[Stable life predection for Psoralea corylifolia by initial average rate stability test].

Jin-Feng Wei1, Zhi-Ping Xue, Jie Liu

  • 1Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|February 13, 2013
PubMed
Summary

The stability of Psoralea corylifolia was assessed using an initial rate stability test. Psoralea corylifolia has a stable shelf life of 0.53 years and should be stored in cool, dark conditions.

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Published on: July 22, 2016

Related Experiment Videos

Last Updated: May 14, 2026

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods
06:12

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods

Published on: April 14, 2023

Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions
05:18

Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions

Published on: July 22, 2016

Area of Science:

  • Pharmacognosy
  • Phytochemistry
  • Analytical Chemistry

Context:

  • Psoralea corylifolia is a traditional medicinal herb.
  • Assessing the quality and shelf-life of herbal medicines is critical for efficacy and safety.

Purpose:

  • To investigate the impact of temperature on the stability of key compounds (psoralea and isopsoralea) in Psoralea corylifolia.
  • To predict the shelf-life of Psoralea corylifolia using an initial average rate stability test.
  • To establish a scientific basis for quality assessment of Psoralea corylifolia.

Summary:

  • The study evaluated the degradation of psoralea and isopsoralea in Psoralea corylifolia under varying temperatures.
  • An initial average rate stability test, utilizing principles of the Arrhenius equation, was employed to determine the storage period.
  • The calculated stable life for Psoralea corylifolia was found to be 0.53 years.

Impact:

  • The findings indicate that elevated temperatures negatively affect the stability of Psoralea corylifolia.
  • Recommendations are provided for optimal storage conditions: a dark and cool environment.
  • This research provides essential data for ensuring the quality and potency of Psoralea corylifolia in pharmaceutical applications.