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[Stable life predection of Hangbaiju and Gongju by classic constant temperature accelerated test method]
Da-Peng Zhang1, Zhi-Ping Xue, Jie Liu
1Institute of Chinese Materia Medica, Henan University, Kaifeng 475004, China.
Objective:
To study the stability of chlorogenic acid, cynaroside and 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju and to predict their term of validity.
Method:
Hangbaiju and Gongju were incubated in an environmental chamber at different temperatures and relative humidities. After the incubation, quantitative determination of chlorogenic acid, cynaroside, 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju were measured by HPLC. The effective period of the preparation was calculated according to Arrhinius index law. Quantitative determination of 3,5-O-discaffeoylquinc acid, cynaroside, chlorogenic acid in Hangju and Gongju were analyzed by HPLC.
Result:
The stable life of Hangbaiju has been determined as 2.25 years. The stable life of Gongju has been determined as 4.31 years.
Conclusion:
The high temperature is not conducive to the stability of Hangbaiju and Gongju, which needs to be placed in a dark and cool place.
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