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Exhaled nitric oxide and lung function after moderate normobaric hyperoxic exposure.

Cecilie Caspersen¹, Trine Stensrud, Michael Storebø

¹Institute of Medicine, University of Bergen, Bergen, Norway.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc

|February 13, 2013

Summary

Exhaled nitric oxide (FE(NO)) significantly decreased after breathing 100% oxygen, but lung function remained stable. This suggests FE(NO) may indicate oxygen exposure, though not necessarily pulmonary oxygen toxicity.

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Area of Science:

Pulmonary Medicine
Respiratory Physiology
Biomarkers

Background:

Pulmonary oxygen toxicity involves airway and alveolar inflammation.
Investigating exhaled nitric oxide (FE(NO)) changes is crucial for understanding oxygen exposure effects.

Purpose of the Study:

To determine if FE(NO) changes correlate with lung function alterations after normobaric hyperoxia (NBO).

Main Methods:

Eighteen healthy subjects underwent NBO (100% O2) and ambient air exposure for 90 minutes.
Lung function tests (volumes, flow rates, ventilation distribution, DLCO) and FE(NO) were measured pre- and post-exposure.

Main Results:

A significant 20% reduction in FE(NO) was observed post-NBO (p < 0.001).
No significant changes were found in lung volumes, maximal expiratory flow rates, DLCO, or ventilation distribution.
No association was detected between FE(NO) changes and lung function variables.

Conclusions:

Reduced FE(NO) indicates oxygen exposure without causing detectable small airway dysfunction or impaired gas exchange.
FE(NO) may serve as an oxygen exposure marker, but its role in pulmonary oxygen toxicity requires further investigation across varied oxygen exposures.