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Pulmonary function measures in healthy infants. Variability and size correction.

J P Hanrahan1, I B Tager, R G Castile

  • 1Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts 02115.

The American Review of Respiratory Disease
|May 1, 1990
PubMed
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Pulmonary function (PF) in infants shows high variability, especially in early life. Sex differences in PF are not significant, but length is a reliable measure for size correction in healthy infants.

Area of Science:

  • Pediatric Pulmonology
  • Infant Physiology
  • Respiratory Mechanics

Background:

  • Pulmonary function (PF) assessment in infants is crucial for diagnosing respiratory conditions.
  • Understanding normal PF development and variability in healthy infants is essential for accurate interpretation.

Purpose of the Study:

  • To examine sex differences and variability in pulmonary function measures in healthy infants.
  • To determine the relationship between somatic size and PF parameters in early life.

Main Methods:

  • 151 pulmonary function tests were performed on 72 healthy infants (<2 years old) using partial expiratory flow volume (PEFV) maneuvers and helium dilution for FRC.
  • Infants were stratified by postconception (PC) age, and PF measures were analyzed for variability and sex differences.

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  • Linear regression was used to assess the relationship between PF parameters and somatic size (length, weight, chest circumference).

    • Main Results:

    • No significant sex differences in PF were observed, even after controlling for somatic size.
    • Flow measures exhibited greater between-subject and within-subject variability than volume measures, particularly in younger infants (<50 PC weeks).
    • All PF measures showed a linear relationship with somatic size; length provided the best size correction.

    Conclusions:

    • Infant pulmonary function measures are most variable in early infancy.
    • Forced expiratory flow measures are more variable than volume measures.
    • Length is linearly related to PF and offers reasonable size correction for healthy infants up to 18 months of age.