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Related Concept Videos

The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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Related Experiment Video

Updated: May 14, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Association between multiple sclerosis and chronic periodontitis: a population-based pilot study.

J-J Sheu1, H-C Lin

  • 1Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan.

European Journal of Neurology
|February 13, 2013
PubMed
Summary
This summary is machine-generated.

Chronic periodontitis (CP) is linked to multiple sclerosis (MS), particularly in women. This study found a significant association between earlier CP diagnosis and MS in female subjects, but not in males.

Related Experiment Videos

Last Updated: May 14, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Area of Science:

  • Neurology
  • Periodontology
  • Epidemiology

Background:

  • Multiple sclerosis (MS) pathogenesis is complex, with infections playing a key role.
  • Chronic periodontitis (CP), a common polymicrobial infection, is investigated for its potential link to MS.

Purpose of the Study:

  • To investigate the association between chronic periodontitis (CP) and multiple sclerosis (MS).
  • To explore potential gender-specific differences in the CP-MS association.

Main Methods:

  • A population-based case-control study in Taiwan.
  • Included 316 MS cases and 1580 controls.
  • Conditional logistic regression analysis was used to assess the association, adjusting for covariates.

Main Results:

  • The prevalence of prior CP was significantly higher in MS cases (25.6%) than controls (15.4%).
  • Individuals with CP were 1.86 times more likely to have MS, after adjusting for confounders.
  • A significant association was observed in females (OR=2.08) but not in males.

Conclusions:

  • Evidence suggests an association between chronic periodontitis and multiple sclerosis, specifically in women.
  • Further research is warranted to confirm these gender-specific findings and explore underlying mechanisms.