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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Updated: May 14, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
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Published on: January 9, 2015

Onychotillomania: clinicopathologic correlations.

Jennifer M Reese1, Kristin D Hudacek, Adam I Rubin

  • 1Division of Dermatopathology, Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.

Journal of Cutaneous Pathology
|February 13, 2013
PubMed
Summary
This summary is machine-generated.

Onychotillomania, a nail disorder from neurotic picking, is hard to diagnose due to denial and mimicry of other conditions. Accurate diagnosis is vital for identifying associated psychiatric disorders.

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Area of Science:

  • Dermatology
  • Psychiatry

Background:

  • Onychotillomania is a rare nail disorder characterized by compulsive picking.
  • Patients often deny the behavior, complicating clinical diagnosis.

Observation:

  • Clinical features of onychotillomania can mimic other inflammatory nail conditions.
  • Histopathologic findings are nonspecific, further challenging diagnosis.

Findings:

  • Accurate diagnosis requires careful correlation of clinical and histopathological findings.
  • Two cases illustrate the diagnostic challenges and the importance of clinical-pathological confrontation.

Implications:

  • Diagnosing onychotillomania is crucial as it can be linked to major depression and OCD.
  • Early identification may facilitate uncovering and treating underlying psychiatric conditions.