Recurrent abruptio placentae in a cynomolgus monkey (Macaca fascicularis)

Area of Science:

• Reproductive Biology
• Primate Models
• Pathology

Background:

• Abruptio placentae is a life-threatening pregnancy complication with poorly understood pathophysiology.
• A history of placental abruption is a significant risk factor in humans.
• This study reports the first case of recurrent abruptio placentae in a Macaca fascicularis.

Observation:

• A pregnant Macaca fascicularis presented with weakness and hypothermia at term gestation.
• Cesarean section revealed retroplacental hemorrhage and partial placental separation.
• The fetus was within the lower birth weight range for the species.

Findings:

• The maternal placenta exhibited extensive necrotic tissue (approximately 60% of the surface).
• Neutrophil infiltration was observed at the placental implantation bed.
• Perivascular lymphocyte collections were noted in the uterine smooth muscle.

Implications:

• This case report emphasizes the role of neutrophil infiltration in abruptio placentae.
• Uterine venous drainage is suggested as a critical factor in the event cascade.
• Findings may inform future research into the pathophysiology of placental abruption in primates.