Related Experiment Video
Updated: May 14, 2026
08:40
TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
Published on: June 8, 2016
The photocrosslinkable tissue adhesive based on copolymeric dextran/HEMA
Tao Wang1, Xueyan Mu, Haibo Li
1Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Carbohydrate Polymers
|February 13, 2013
Summary
We developed a novel copolymeric tissue adhesive using dextran and HEMA. This bioadhesive system shows significantly improved adhesion strength and non-toxicity, offering a promising alternative for wound closure applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Tissue Engineering
Background:
- Biopolymer dextran is a versatile base for developing advanced medical materials.
- Tissue adhesives are crucial for wound closure, with ongoing needs for improved performance and safety.
Purpose of the Study:
- To develop and characterize a novel copolymeric bioadhesive system based on dextran for tissue adhesion.
- To evaluate the impact of incorporating 2-hydroxyethyl methacrylate (HEMA) on the properties of dextran-based hydrogels.
Main Methods:
- Copolymeric hydrogels of urethane dextran (Dex-U) and HEMA were synthesized and crosslinked using ultraviolet (UV) irradiation.
- Photopolymerization was monitored using real-time infrared spectroscopy (RTIR).
- Adhesion strength was assessed via lap-shear tests, alongside surface tension, viscosity, and cytotoxicity assays.
Main Results:
- The addition of HEMA to the dextran-based system (Dex-H) significantly enhanced adhesion strength and reduced toxicity compared to the Dex-U system alone.
- The maximum adhesion strength achieved was 4.33±0.47 MPa, which is 86 times greater than that of Tisseel.
- The copolymeric adhesives demonstrated promising biocompatibility and tunable properties for specific tissue applications.
Conclusions:
- The developed copolymeric dextran-HEMA hydrogels represent a highly effective and safe bioadhesive for potential use in medical applications.
- These advanced materials show significant potential to overcome limitations of current tissue adhesives, offering superior performance.
- Further research and development could lead to clinical applications of these promising tissue adhesives.
