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Related Experiment Video

Updated: May 14, 2026

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion
09:09

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion

Published on: April 12, 2020

Deciphering the 8q24.21 association for glioma.

Victor Enciso-Mora1, Fay J Hosking, Ben Kinnersley

  • 1Division of Genetics and Epidemiology, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

Human Molecular Genetics
|February 13, 2013
PubMed
Summary

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A specific genetic variant, rs55705857, strongly influences glioma risk, particularly in non-glioblastoma tumors. This finding pinpoints a key genetic factor in glioma development.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Previous studies identified tag single nucleotide polymorphisms (tagSNPs) at 8q24.21 associated with glioma risk.
  • The precise functional variant and its role in glioma etiology remained unclear.

Purpose of the Study:

  • To fine-map the 8q24.21 locus and identify the specific genetic variant responsible for glioma risk.
  • To investigate the association of this variant with different glioma subtypes.

Main Methods:

  • Utilized data from four genome-wide association studies (GWAS) including 4147 glioma cases and 7435 controls.
  • Imputed genotypes using 1000 Genomes Project data and high-coverage sequencing for enhanced marker density.
  • Performed association analyses stratified by glioma subtype and validated findings in independent datasets.

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On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis
06:48

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis

Published on: May 31, 2020

Related Experiment Videos

Last Updated: May 14, 2026

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion
09:09

Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion

Published on: April 12, 2020

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis
06:48

On-Site Sampling and Extraction of Brain Tumors for Metabolomics and Lipidomics Analysis

Published on: May 31, 2020

Main Results:

  • Identified a low-frequency single nucleotide polymorphism, rs55705857, that fully captured the 8q24.21 glioma association (P = 2.24 × 10⁻³⁸).
  • The association of rs55705857 was predominantly observed in non-glioblastoma (non-GBM) tumors (P = 1.07 × 10⁻⁶⁷).
  • rs55705857 showed a significant odds ratio of 4.3 for low-grade glioma (P = 2.31 × 10⁻⁹⁴) and maps to a conserved region within the CCDC26 long non-coding RNA.

Conclusions:

  • rs55705857 is the primary causal variant at 8q24.21 influencing glioma risk, particularly for non-GBM subtypes.
  • The variant's location within a conserved non-coding RNA suggests a potential functional role in glioma development.
  • These findings enhance understanding of the genetic underpinnings of glioma etiology.