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Related Experiment Video

Updated: May 14, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

[Insights into melanoma from a pathologist's perspective].

D Mihic-Probst¹, M Beer

¹Institut für klinische Pathologie, Universitätsspital Zürich, Schmelzbergstrasse 12, 8091 Zürich. daniela.mihic@usz.ch

|February 13, 2013

Summary

Early detection of malignant melanoma, a leading cause of skin cancer death, is crucial. Molecular pathology, including BRAF mutation testing, aids in early diagnosis and targeted therapies for better patient outcomes.

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Last Updated: May 14, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

Oncology
Dermatology
Molecular Pathology

Context:

Malignant melanoma is the leading cause of skin cancer mortality.
Early-stage localized melanoma is primarily treated with surgical excision.
Identifying early-stage tumors is critical for effective treatment.

Purpose:

To review molecular pathology methods in melanoma research.
To highlight the significance of BRAF V600 mutation detection.
To discuss BRAF-inhibiting targeted therapy and melanoma heterogeneity.

Summary:

Molecular pathology has become integral to melanoma research.
BRAF V600 mutation testing is a key diagnostic and therapeutic marker.
Melanoma exhibits heterogeneity, evidenced by drug resistance and stem-cell-like populations.

Impact:

Advances in molecular pathology improve early melanoma detection.
Targeted therapies, like BRAF inhibitors, offer new treatment avenues.
Understanding melanoma heterogeneity guides the development of novel combination therapies.