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Low 25-OH vitamin D is associated with benign prostatic hyperplasia
Mohammad-Ali Haghsheno1, Dan Mellström, Carl-Johan Behre
1Department of Urology, Institute of Clinical Sciences, Sahlgrenska University Hospital, Goteborg, Sweden. mohammad.haghsheno@vgregion.se
The Journal of Urology
|February 13, 2013
Summary
Low vitamin D levels and high serum calcium, sex hormone-binding globulin, and HDL cholesterol are linked to benign prostatic hyperplasia (BPH). This study identifies key factors associated with BPH in older men.
Area of Science:
- Urology
- Endocrinology
- Nutritional Science
Background:
- Benign prostatic hyperplasia (BPH) is a common condition in aging men.
- Factors influencing BPH development are not fully understood.
- Vitamin D and hormonal/metabolic factors are potential contributors.
Purpose of the Study:
- To investigate the association between vitamin D levels and BPH.
- To explore the relationship between body composition, sex hormones, and BPH.
- To identify other metabolic and endocrine factors linked to BPH.
Main Methods:
- Cross-sectional study of 155 men aged 72-76 from the Gothenburg MrOS cohort.
- BPH assessed by total prostate volume.
- Univariate and multivariate regression analyses used to evaluate associations.
Main Results:
- Low 25-hydroxyvitamin D (25-OH vitamin D) was inversely associated with prostate size.
- Albumin-corrected serum calcium, sex hormone-binding globulin, and high-density lipoprotein (HDL) cholesterol also showed inverse associations with prostate volume.
- No significant associations were found for body composition, other hormones, adiponectin, or lipid status.
Conclusions:
- Low 25-OH vitamin D, serum calcium, sex hormone-binding globulin, and HDL cholesterol are independently associated with BPH.
- These findings suggest potential roles for vitamin D and metabolic factors in BPH pathogenesis.
- Further research is warranted to confirm these associations and explore therapeutic implications.
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